Hydrochloric Acid → HCID 67446199, compound

HRID 1255431Notes

Reaction equation

HRID 1255431 reaction equation
[ClH:1].[F:2][C:3]1([F:16])[CH2:7][CH2:6][C@@H:5]([NH:8]C(=O)OC(C)(C)C)[CH2:4]1>O1CCOCC1>[ClH:1].[F:2][C:3]1([F:16])[CH2:7][CH2:6][C@@H:5]([NH2:8])[CH2:4]1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 58484972HCID 58484972, compound

Product 1

HCID 67446199HCID 67446199, compoundYield 82%

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

Hydrochloric acid (4M in dioxane, 60 mL) was added to a solution of (R)-tert-butyl 3,3-difluorocyclopentylcarbamate (4.61 g, 20.8 mmol) in dioxane (40 mL) at 0° C. After complete addition, the reaction mixture was allowed to warm to room temperature and stirred for 2 hours. The solvent was removed in vacuo and the residue was triturated with diethylether to afford the title compound as an off-white solid (2.68 g, 82% yield).

Workup

  1. additionAfter complete addition
  2. customThe solvent was removed in vacuo
  3. customthe residue was triturated with diethylether

Sources & evidence

ORD record
ord-f471a62e11134988ab242a1997f0de4c
Source dataset
uspto-grants-2013_06
Patent number
US08461149B2

Reaction notes

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