Hydrazine hydrate (1:1) → HCID 178514432, compound

HRID 1255467Notes

Reaction equation

HRID 1255467 reaction equation
C[O:2][C:3]([C@H:5]1[CH2:10][CH2:9][C@H:8]([O:11][C:12]2[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=2)[CH2:7][CH2:6]1)=O.O.[NH2:19][NH2:20]>>[O:11]([C@H:8]1[CH2:9][CH2:10][C@H:5]([C:3]([NH:19][NH2:20])=[O:2])[CH2:6][CH2:7]1)[C:12]1[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=1

Participants

3

Reactant 2

HCID 24654Hydrazine hydrate (1:1)HCID 178501257HCID 178501257, compound

Product 1

HCID 178514432HCID 178514432, compound

Conditions

Temperature
120 °C

Procedure

A mixture of trans-4-phenoxy-cyclohexanecarboxylic acid methyl ester (1.07 g, 4.57 mmol) and hydrazine hydrate (0.22 g, 4.48 mmol) was heated at 120° C. for 4 h. After cooling to room temperature the reaction mixture was concentrated in vacuo to give the crude title compound as white solid in quantitative yield, which was used in the next step without further purification.

Workup

  1. temperatureAfter cooling to room temperature the reaction mixture
  2. concentrationwas concentrated in vacuo

Sources & evidence

ORD record
ord-3e0f519745c74784a309ab587ea045e2
Source dataset
uspto-grants-2013_06
Patent number
US08461152B2

Reaction notes

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