Hydrazine hydrate (1:1) → HCID 178424399, compound

HRID 1255474Notes

Reaction equation

HRID 1255474 reaction equation
C[O:2][C:3]([C@H:5]1[CH2:10][CH2:9][C@H:8]([O:11][C:12]2[CH:17]=[CH:16][CH:15]=[CH:14][C:13]=2[CH3:18])[CH2:7][CH2:6]1)=O.O.[NH2:20][NH2:21]>C1(C)C=CC=CC=1>[C:13]1([CH3:18])[CH:14]=[CH:15][CH:16]=[CH:17][C:12]=1[O:11][C@H:8]1[CH2:9][CH2:10][C@H:5]([C:3]([NH:20][NH2:21])=[O:2])[CH2:6][CH2:7]1

Participants

4

Reactant 2

HCID 24654Hydrazine hydrate (1:1)HCID 178501258HCID 178501258, compound

Product 1

HCID 178424399HCID 178424399, compoundYield 816.6%

Reagents, catalysts & solvents 1

HCID 1140TolueneSolvent

Conditions

Temperature
120 °C

Procedure

A mixture of trans-4-o-tolyloxy-cyclohexanecarboxylic acid methyl ester (0.091 g, 0.36 mmol) and hydrazine hydrate (0.02 ml, 0.36 mmol) was heated at 120° C. for 22 h. After cooling to room temperature the reaction mixture was suspended in toluene. After evaporation of the solvent the residue was dried in high vacuo (1-2 mbar) to give the crude title compound (0.73 g, 81%) as white solid, which was used in the next step without further purification.

Workup

  1. temperatureAfter cooling to room temperature the reaction mixture
  2. customAfter evaporation of the solvent the residue
  3. customwas dried in high vacuo (1-2 mbar)

Sources & evidence

ORD record
ord-5a6a928a640c4b2b90a3c7c28214d1b7
Source dataset
uspto-grants-2013_06
Patent number
US08461152B2

Reaction notes

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