Hydrazine hydrate (1:1) → HCID 178514440, compound

HRID 1255475Notes

Reaction equation

HRID 1255475 reaction equation
C[O:2][C:3]([C@H:5]1[CH2:10][CH2:9][C@H:8]([O:11][C:12]2[CH:17]=[C:16]([F:18])[CH:15]=[C:14]([F:19])[CH:13]=2)[CH2:7][CH2:6]1)=O.O.[NH2:21][NH2:22]>>[F:19][C:14]1[CH:13]=[C:12]([CH:17]=[C:16]([F:18])[CH:15]=1)[O:11][C@H:8]1[CH2:9][CH2:10][C@H:5]([C:3]([NH:21][NH2:22])=[O:2])[CH2:6][CH2:7]1

Participants

3

Reactant 2

HCID 24654Hydrazine hydrate (1:1)HCID 178501281HCID 178501281, compound

Product 1

HCID 178514440HCID 178514440, compound

Conditions

Temperature
120 °C

Procedure

A mixture of trans-4-(3,5-difluoro-phenoxy)-cyclohexanecarboxylic acid methyl ester (0.148 g, 0.548 mmol) and hydrazine hydrate (0.106 ml, 2.19 mmol) was heated at 120° C. for 18 h. After cooling to room temperature the reaction mixture was partitioned between ethyl acetate (50 ml) and 1 M aqueous sodium hydroxide solution (50 ml). The organic layer was separated.

Workup

  1. temperatureAfter cooling to room temperature the reaction mixture
  2. customwas partitioned between ethyl acetate (50 ml) and 1 M aqueous sodium hydroxide solution (50 ml)
  3. customThe organic layer was separated

Sources & evidence

ORD record
ord-fbaed8bc585a4934866815473566d119
Source dataset
uspto-grants-2013_06
Patent number
US08461152B2

Reaction notes

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