Triethylamine → HCID 136052975, compound

HRID 1255516Notes

Reaction equation

HRID 1255516 reaction equation
[CH2:1]([CH:4]([C:19]([O:21]C1C(Cl)=C(Cl)C(Cl)=C(Cl)C=1Cl)=O)[C:5]([O:7]C1C(Cl)=C(Cl)C(Cl)=C(Cl)C=1Cl)=O)[CH:2]=[CH2:3].C(N(CC)CC)C.[NH2:40][C:41]1[CH:46]=[C:45]([O:47][CH3:48])[CH:44]=[CH:43][N:42]=1>CC(C)=O>[CH2:1]([C:4]1[C:5](=[O:7])[N:42]2[CH:43]=[CH:44][C:45]([O:47][CH3:48])=[CH:46][C:41]2=[N:40][C:19]=1[OH:21])[CH:2]=[CH2:3]

Participants

5

Reactant 3

HCID 8471TriethylamineHCID 108987152-Amino-4-MethoxypyridineHCID 12339696HCID 12339696, compound

Product 1

HCID 136052975HCID 136052975, compoundYield 65%

Reagents, catalysts & solvents 1

HCID 180AcetoneSolvent

Procedure

Bis(pentachlorophenyl) allylmalonate (905 mg, 1.412 mmol) and triethylamine (0.359 ml, 2.58 mmol) were added to a slurry of 2-amino-4-methoxypyridine (160 mg, 1.289 mmol) in acetone (6.5 ml). The slurry was stirred for 16 hours, filtered, and washed with acetone to yield the title compound as a white solid (194 mg, 65%). LCMS (ES+) m/z 233.0 (M+H)+.

Workup

  1. filtrationfiltered
  2. washwashed with acetone

Sources & evidence

ORD record
ord-67e4831a23ee48b4b0c942c5c1d2f641
Source dataset
uspto-grants-2013_06
Patent number
US08461107B2

Reaction notes

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