Ethanol → HCID 66969198, compound

HRID 1255527Notes

Reaction equation

HRID 1255527 reaction equation
[CH:1]1([CH:6]2[C:31](=[O:32])[N:30]3[CH2:33][CH:27]([CH2:28][CH:29]3[C:34]([O-:36])=[O:35])[O:26][C:25]3[N:20]([C:21](=[O:37])[CH:22]=[CH:23][CH:24]=3)[CH2:19][CH:18]=[CH:17][CH2:16][CH2:15][CH:14]3[CH:10]([CH2:11][CH2:12][CH2:13]3)[O:9][C:8](=[O:38])[NH:7]2)[CH2:5][CH2:4][CH2:3][CH2:2]1.[CH2:39](O)C>>[CH:1]1([C@H:6]2[C:31](=[O:32])[N:30]3[CH2:33][C@@H:27]([CH2:28][C@H:29]3[C:34]([O:36][CH3:39])=[O:35])[O:26][C:25]3[N:20]([C:21](=[O:37])[CH:22]=[CH:23][CH:24]=3)[CH2:19][CH2:18][CH2:17][CH2:16][CH2:15][C@H:14]3[C@@H:10]([CH2:11][CH2:12][CH2:13]3)[O:9][C:8](=[O:38])[NH:7]2)[CH2:2][CH2:3][CH2:4][CH2:5]1

Participants

3

Reactant 2

HCID 702EthanolHCID 86651352HCID 86651352, compound

Product 1

HCID 66969198HCID 66969198, compoundYield 94%

Procedure

The title compound was prepared in a similar manner as Example 13 Step 1, utilizing methyl (1R,10E, and 10Z,14S,18R,22S,25S)-22-cyclopentyl-7,20,23-trioxo-2,19-dioxa-8,21,24-triazatetracyclo[22.2.1.03,8.014,18]heptacosa-3,5,10-triene-25-carboxylate and replacing THF with ethanol as the solvent to give a 94% yield. LCMS (ES+) m/z 544.3 (M+H)+.

Workup

  1. customto give a 94% yield

Sources & evidence

ORD record
ord-e558c31c6ff94d4799482014b6d38d2f
Source dataset
uspto-grants-2013_06
Patent number
US08461107B2

Reaction notes

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