3,4-dihydro-2H-pyran → HCID 86636416, compound

HRID 1255627Notes

Reaction equation

HRID 1255627 reaction equation
[Br:1][C:2]1[CH:18]=[CH:17][C:5]([O:6][C:7]2[CH:14]=[CH:13][C:10]([C:11]#[N:12])=[CH:9][C:8]=2[CH:15]=[O:16])=[CH:4][C:3]=1[CH2:19][OH:20].[O:21]1[CH:26]=[CH:25][CH2:24][CH2:23][CH2:22]1.C(=O)([O-])[O-].[Na+].[Na+].O.C(Cl)(Cl)Cl>ClCCl.CC1(C)[C@]2(CS(O)(=O)=O)C(C[C@H]1CC2)=O>[Br:1][C:2]1[CH:18]=[CH:17][C:5]([O:6][C:7]2[CH:14]=[CH:13][C:10]([C:11]#[N:12])=[CH:9][C:8]=2[CH:15]=[O:16])=[CH:4][C:3]=1[CH2:19][O:20][CH:22]1[CH2:23][CH2:24][CH2:25][CH2:26][O:21]1

Participants

7

Reactant 4

HCID 80803,4-dihydro-2H-pyranHCID 10340Sodium CarbonateHCID 22418719Chloroform waterHCID 86636415HCID 86636415, compound

Product 1

HCID 86636416HCID 86636416, compoundYield 88%

Reagents, catalysts & solvents 2

HCID 65617D-Camphorsulfonic AcidCatalystHCID 6344DichloromethaneSolvent

Procedure

A mixture of 4-[4-bromo-3-(hydroxymethyl)phenoxy]-3-formylbenzonitrile (25.5 g, 76.8 mmol), 3,4-dihydro-2H-pyran (10.4 mL, 115 mmol), and dl-10-camphorsulfonic acid (356 mg, 2 mol %) in dichloromethane (300 mL) was stirred at room temperature for 2 h. Sodium carbonate (3 g) was added, and the mixture was poured into water/chloroform. The organic layer was washed with brine and dried on anhydrous sodium sulfate. The solvent was removed under reduced pressure, and the residue was purified by silica gel column (85:15 hexane/ethyl acetate) to give 4-[4-bromo-3-(2-tetrahydropyranyloxymethyl)phenoxy]-3-formylbenzonitrile (28.0 g, 88%).

Workup

  1. washThe organic layer was washed with brine
  2. dry with materialdried on anhydrous sodium sulfate
  3. customThe solvent was removed under reduced pressure
  4. customthe residue was purified by silica gel column (85:15 hexane/ethyl acetate)

Sources & evidence

ORD record
ord-40274a7ba3fe480d9af792cfe6e87e04
Source dataset
uspto-grants-2013_06
Patent number
US08461135B2

Reaction notes

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