Hydrochloric Acid → HCID 67439874, compound

HRID 1255668Notes

Reaction equation

HRID 1255668 reaction equation
C([C:3]1[CH:4]=[C:5]([CH:21]=[CH:22][C:23]=1[B:24]1[O:28]C(C)(C)[C:26](C)(C)[O:25]1)[O:6][C:7]1[CH:14]=[CH:13][C:10]([C:11]#[N:12])=[C:9]([N:15]([CH2:17][CH2:18][O:19][CH3:20])[CH3:16])[N:8]=1)=O.[BH4-].[Na+].Cl>CO>[OH:28][B:24]1[C:23]2[CH:22]=[CH:21][C:5]([O:6][C:7]3[CH:14]=[CH:13][C:10]([C:11]#[N:12])=[C:9]([N:15]([CH2:17][CH2:18][O:19][CH3:20])[CH3:16])[N:8]=3)=[CH:4][C:3]=2[CH2:26][O:25]1

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 4311764Sodium borohydrideHCID 86636426HCID 86636426, compound

Product 1

HCID 67439874HCID 67439874, compoundYield 26%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

To a clear solution of 6-[3-formyl-4-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-phenoxy]-2-[(2-methoxy-ethyl)-methyl-amino]-nicotinonitrile (7) (15 g, 343 mmol) in MeOH (anhydrous, 300 mL) was slowly added NaBH4 (7.83 g, 206 mmol). The reaction was stirred at room temperature 4 hours, before the addition of HCl solution (1 M, 200 mL). The stirring was kept at room temperature overnight. Then the solution was slowly evaporated in vacuo. Purification was accomplished by reverse phase Biotage with 10%-100% MeOH/H2O gradient to afford 3 g (26% yield) of the title compound. 1H NMR (400 MHz, CHLOROFORM-d) δ ppm 7.74 (d, J=8.6 Hz, 1H), 7.70 (d, J=8.2 Hz, 1H), 7.13-7.09 (m, 2H), 6.23 (d, J=8.2 Hz, 1H), 5.08 (s, 2H), 4.78 (s, 1H), 3.56 (t, J=5.7 Hz, 2H), 3.36 (t, J=5.7 Hz, 2H), 3.27 (s, 3H), 3.23 (s, 3H); ES-MS: m/z 340 (M+H)+; HPLC: 99.38% (220 nm), 98.71% (MaxPlot).

Workup

  1. customThen the solution was slowly evaporated in vacuo
  2. customPurification

Sources & evidence

ORD record
ord-9b56547b185b4e85beec686fbb8a15b5
Source dataset
uspto-grants-2013_06
Patent number
US08461135B2

Reaction notes

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