tert-butyl N-(methylcarbamothioyl)carbamate → [(S)-4-(2-fluoro-5-nitro-phenyl)-1,4-dimethyl-6-oxo-1,4,5,6-tetrahydro-pyrimidin-2-yl]-carbamic acid tert-butyl ester

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Reaction Steps

Starting from (S)-3-amino-3-(2-fluoro-5-nitro-phenyl)-butyric acid methyl ester (14.8 mmole) and tert-butyl [(methylamino)carbonothioyl]carbamate, the product [(S)-4-(2-fluoro-5-nitro-phenyl)-1,4-dimethyl-6-oxo-1,4,5,6-tetrahydro-pyrimidin-2-yl]-carbamic acid tert-butyl ester (3.13 g) was obtained as pale yellow foam. MS (ESI): m/z=381.2 [ M+H]+.

Provenance & Evidence