4-Chloropyridine-2-carboxylic acid → HCID 49820224, compound

HRID 1255788Notes

Reaction equation

HRID 1255788 reaction equation
C(OC(=O)[NH:7][C:8]1[N:9]([CH3:23])[C:10](=[O:22])[CH2:11][C@:12]([C:15]2[CH:20]=[CH:19][CH:18]=[C:17]([NH2:21])[CH:16]=2)([CH3:14])[N:13]=1)(C)(C)C.[Cl:25][C:26]1[CH:31]=[CH:30][N:29]=[C:28]([C:32](O)=[O:33])[CH:27]=1>>[NH2:7][C:8]1[N:9]([CH3:23])[C:10](=[O:22])[CH2:11][C@:12]([C:15]2[CH:16]=[C:17]([NH:21][C:32]([C:28]3[CH:27]=[C:26]([Cl:25])[CH:31]=[CH:30][N:29]=3)=[O:33])[CH:18]=[CH:19][CH:20]=2)([CH3:14])[N:13]=1

Participants

3

Reactant 2

HCID 2308904-Chloropyridine-2-carboxylic acidHCID 57496586HCID 57496586, compound

Product 1

HCID 49820224HCID 49820224, compound

Procedure

The coupling of [(S)-4-(3-amino-phenyl)-1,4-dimethyl-6-oxo-1,4,5,6-tetrahydro-pyrimidin-2-yl]-carbamic acid tert-butyl ester from experiment F1 and 4-chloro-pyridine-2-carboxylic acid followed by deprotection of the intermediate yielded the title compound as a colourless solid. MS (ESI): m/z=372.1 [ M+H]+.

Sources & evidence

ORD record
ord-5d2eb893718b41dd832c85308b2f6a19
Source dataset
uspto-grants-2013_06
Patent number
US08461160B2

Reaction notes

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