Sulfuric Acid → HCID 17953125, compound

HRID 1255923Notes

Reaction equation

HRID 1255923 reaction equation
[Br:1][C:2]1[CH:3]=[C:4]([CH2:8][C:9]#[N:10])[CH:5]=[N:6][CH:7]=1.[OH:11]S(O)(=O)=O>CCO.O>[Br:1][C:2]1[CH:3]=[C:4]([CH2:8][C:9]([NH2:10])=[O:11])[CH:5]=[N:6][CH:7]=1

Participants

5

Reactant 2

HCID 1118Sulfuric AcidHCID 150054172-(5-Bromopyridin-3-yl)acetonitrile

Product 1

HCID 17953125HCID 17953125, compound

Reagents, catalysts & solvents 2

HCID 702EthanolSolventHCID 962WaterSolvent

Conditions

Temperature
-110 °C

Procedure

(5-Bromo-pyridin-3-yl)-acetonitrile (1 g, 5.1 mmol) was dissolved in a mixture of EtOH (20 ml) and water (1.2 ml). H2SO4 (6.8 ml) was then added to the mixture and the mixture was heated at −110° C. for 24 hrs. Solvent was removed under vacuo, taken up in EtOAc and washed with 2N Na2CO3 solution. Drying and evaporation gave a crude oil which was sufficiently pure for the next step.

Workup

  1. customSolvent was removed under vacuo
  2. washwashed with 2N Na2CO3 solution
  3. customDrying
  4. customevaporation
  5. customgave a crude oil which

Sources & evidence

ORD record
ord-348d77ff5445400086ebb5ba54b3888f
Source dataset
uspto-grants-2013_06
Patent number
US08461167B2

Reaction notes

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