HRID1255954

反应详情

EQUATION

反应方程式

REACTANTS

反应物

结构：C#Cc1cc(C(=O)Nc2ccc(CN3CCN(C)CC3)c(C(F)(F)F)c2)ccc1C

HCID57737398

未命名化合物

HCID86632314

未命名化合物

PRODUCTS

生成物

结构：Cc1ccc(C(=O)Nc2ccc(CN3CCN(C)CC3)c(C(F)(F)F)c2)cc1C#Cc1cnc(CC(N)=O)cn1

HCID57775113

3-{[5-(2-amino-2-oxoethyl)pyrazin-2-yl]ethynyl}-4-methyl-N-{4-[(4-methylpiperazin-1-yl)methyl]-3-(trifluoromethyl)phenyl}benzamide

C29H29F3N6O2

PROCEDURE

实验过程

The title compound can be prepared as for example 1 using 2-(5-bromopyrazin-2-yl)acetamide and 3-ethynyl-4-methyl-N-{4-(4-methyl-piperazin-1-ylmethyl)-3-trifluoromethyl-phenyl}-benzamide.

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-83dc0755cfb94ebe8774f54d4214af25
来源数据集: uspto-grants-2013_06
DOI: 10.6084/m9.figshare.5104873.v1
专利: US08461167B2
来源说明: uspto-grants-2013_06

反应 SMILES

Br[C:2]1[N:3]=[CH:4][C:5]([CH2:8][C:9]([NH2:11])=[O:10])=[N:6][CH:7]=1.[C:12]([C:14]1[CH:15]=[C:16]([CH:38]=[CH:39][C:40]=1[CH3:41])[C:17]([NH:19][C:20]1[CH:25]=[CH:24][C:23]([CH2:26][N:27]2[CH2:32][CH2:31][N:30]([CH3:33])[CH2:29][CH2:28]2)=[C:22]([C:34]([F:37])([F:36])[F:35])[CH:21]=1)=[O:18])#[CH:13]>>[NH2:11][C:9](=[O:10])[CH2:8][C:5]1[N:6]=[CH:7][C:2]([C:13]#[C:12][C:14]2[CH:15]=[C:16]([CH:38]=[CH:39][C:40]=2[CH3:41])[C:17]([NH:19][C:20]2[CH:25]=[CH:24][C:23]([CH2:26][N:27]3[CH2:28][CH2:29][N:30]([CH3:33])[CH2:31][CH2:32]3)=[C:22]([C:34]([F:35])([F:37])[F:36])[CH:21]=2)=[O:18])=[N:3][CH:4]=1