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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1255954Generated: November 3, 2026

3-ethynyl-4-methyl-N-(4-((4-methylpiperazin-1-yl)methyl)-3-(trifluoromethyl)phenyl)benzamide → 3-{[5-(2-amino-2-oxoethyl)pyrazin-2-yl]ethynyl}-4-methyl-N-{4-[(4-methylpiperazin-1-yl)methyl]-3-(trifluoromethyl)phenyl}benzamide

https://huagongshe.com/reaction/1255954

Reaction equation

Participants

RoleNameHCIDCharge
Reactant3-ethynyl-4-methyl-N-(4-((4-methylpiperazin-1-yl)methyl)-3-(trifluoromethyl)phenyl)benzamideHCID 57737398—
Reactant2-(5-Bromopyrazin-2-yl)acetamideHCID 86632314—
Product3-{[5-(2-amino-2-oxoethyl)pyrazin-2-yl]ethynyl}-4-methyl-N-{4-[(4-methylpiperazin-1-yl)methyl]-3-(trifluoromethyl)phenyl}benzamideHCID 57775113—

Reaction Steps

The title compound can be prepared as for example 1 using 2-(5-bromopyrazin-2-yl)acetamide and 3-ethynyl-4-methyl-N-{4-(4-methyl-piperazin-1-ylmethyl)-3-trifluoromethyl-phenyl}-benzamide.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08461167B2
Source datasetuspto-grants-2013_06
ORD IDord-83dc0755cfb94ebe8774f54d4214af25
Source noteuspto-grants-2013_06