Indole → 3-(2-chloro-5-fluoropyrimidin-4-yl)-1H-indole

HRID 1255988Notes

Reaction equation

HRID 1255988 reaction equation
[Cl:1][C:2]1[N:7]=[C:6](Cl)[C:5]([F:9])=[CH:4][N:3]=1.[NH:10]1[C:18]2[C:13](=[CH:14][CH:15]=[CH:16][CH:17]=2)[CH:12]=[CH:11]1>>[Cl:1][C:2]1[N:7]=[C:6]([C:12]2[C:13]3[C:18](=[CH:17][CH:16]=[CH:15][CH:14]=3)[NH:10][CH:11]=2)[C:5]([F:9])=[CH:4][N:3]=1

Participants

3

Reactant 2

HCID 798IndoleHCID 2507052,4-Dichloro-5-fluoropyrimidine

Product 1

HCID 580714353-(2-chloro-5-fluoropyrimidin-4-yl)-1H-indole

Procedure

Starting materials: 2,4-dichloro-5-fluoropyrimidine and 1H-indole. m/z 248.

Sources & evidence

ORD record
ord-df2e1829608d4b8ca28aed120e540a04
Source dataset
uspto-grants-2013_06
Patent number
US08461170B2

Reaction notes

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