1,4-Dioxa-8-azaspiro(4.5)decane → 8-(5-Methoxy-2-methyl-4-nitrophenyl)-1,4-dioxa-8-azaspiro[4.5]decane

HRID 1256000Notes

Reaction equation

HRID 1256000 reaction equation
F[C:2]1[CH:7]=[C:6]([O:8][CH3:9])[C:5]([N+:10]([O-:12])=[O:11])=[CH:4][C:3]=1[CH3:13].[O:14]1[C:18]2([CH2:23][CH2:22][NH:21][CH2:20][CH2:19]2)[O:17][CH2:16][CH2:15]1>>[CH3:9][O:8][C:6]1[C:5]([N+:10]([O-:12])=[O:11])=[CH:4][C:3]([CH3:13])=[C:2]([N:21]2[CH2:22][CH2:23][C:18]3([O:17][CH2:16][CH2:15][O:14]3)[CH2:19][CH2:20]2)[CH:7]=1

Participants

3

Reactant 2

HCID 674351,4-Dioxa-8-azaspiro(4.5)decaneHCID 184681411-Fluoro-5-methoxy-2-methyl-4-nitrobenzene2×

Product 1

HCID 580714988-(5-Methoxy-2-methyl-4-nitrophenyl)-1,4-dioxa-8-azaspiro[4.5]decane

Procedure

Starting Materials: 1-fluoro-5-methoxy-2-methyl-4-nitrobenzene (INTERMEDIATE 7) and 1,4-dioxa-8-azaspiro[4.5]decane. m/z 309.

Sources & evidence

ORD record
ord-8786629b0f594d7eb6821508661acffe
Source dataset
uspto-grants-2013_06
Patent number
US08461170B2

Reaction notes

Loading…