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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1256000Generated: October 31, 2026

1,4-Dioxa-8-azaspiro(4.5)decane → 8-(5-Methoxy-2-methyl-4-nitrophenyl)-1,4-dioxa-8-azaspiro[4.5]decane

https://huagongshe.com/reaction/1256000

Reaction equation

Participants

RoleNameHCIDCharge
Reactant1,4-Dioxa-8-azaspiro(4.5)decaneHCID 67435—
Reactant1-Fluoro-5-methoxy-2-methyl-4-nitrobenzeneHCID 18468141—
Product8-(5-Methoxy-2-methyl-4-nitrophenyl)-1,4-dioxa-8-azaspiro[4.5]decaneHCID 58071498—

Reaction Steps

Starting Materials: 1-fluoro-5-methoxy-2-methyl-4-nitrobenzene (INTERMEDIATE 7) and 1,4-dioxa-8-azaspiro[4.5]decane. m/z 309.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08461170B2
Source datasetuspto-grants-2013_06
ORD IDord-8786629b0f594d7eb6821508661acffe
Source noteuspto-grants-2013_06