3-Fluoropyrrolidine → (R)-4-(3-Fluoropyrrolidin-1-yl)-1-(3-methoxy-4-nitrophenyl)piperidine

HRID 1256006Notes

Reaction equation

HRID 1256006 reaction equation
[CH3:1][O:2][C:3]1[CH:4]=[C:5]([N:12]2[CH2:17][CH2:16][C:15](=O)[CH2:14][CH2:13]2)[CH:6]=[CH:7][C:8]=1[N+:9]([O-:11])=[O:10].[F:19][C@@H:20]1[CH2:24][CH2:23][NH:22][CH2:21]1>>[F:19][C@@H:20]1[CH2:24][CH2:23][N:22]([CH:15]2[CH2:16][CH2:17][N:12]([C:5]3[CH:6]=[CH:7][C:8]([N+:9]([O-:11])=[O:10])=[C:3]([O:2][CH3:1])[CH:4]=3)[CH2:13][CH2:14]2)[CH2:21]1

Participants

3

Reactant 2

HCID 27591633-FluoropyrrolidineHCID 259188571-(3-Methoxy-4-nitrophenyl)piperidin-4-one2×

Product 1

HCID 58071437(R)-4-(3-Fluoropyrrolidin-1-yl)-1-(3-methoxy-4-nitrophenyl)piperidine

Procedure

Starting materials: 1-(3-methoxy-4-nitrophenyl)piperidin-4-one (INTERMEDIATE 18) and (R)-3-fluoropyrrolidine. m/z 324.

Sources & evidence

ORD record
ord-4ba98812076744dabb9abd192f680e6f
Source dataset
uspto-grants-2013_06
Patent number
US08461170B2

Reaction notes

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