Trifluoroacetic acid → 3,3-Dimethylpiperidin-4-one

HRID 1256012Notes

Reaction equation

HRID 1256012 reaction equation
FC(F)(F)C(O)=O.[CH3:8][C:9]1([CH3:23])[C:14](=[O:15])[CH2:13][CH2:12][N:11](C(OC(C)(C)C)=O)[CH2:10]1>ClCCl>[CH3:8][C:9]1([CH3:23])[C:14](=[O:15])[CH2:13][CH2:12][NH:11][CH2:10]1

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 22278899tert-Butyl 3,3-dimethyl-4-oxopiperidine-1-carboxylate

Product 1

HCID 222788373,3-Dimethylpiperidin-4-one

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

Trifluoroactic acid (4 mL, 51.92 mmol) was added to a solution of tert-butyl 3,3-dimethyl-4-oxopiperidine-1-carboxylate (2.0588 g, 9.06 mmol) in dichloromethane (12 mL). The reaction was stirred at RT for 2 h and the solution was concentrated to remove the solvent. The residue as the product was directly used in the next step without further purification. m/z 128.

Workup

  1. concentrationthe solution was concentrated
  2. customto remove the solvent
  3. customThe residue as the product was directly used in the next step without further purification

Sources & evidence

ORD record
ord-628297f4fa6f499cbdfe6b9c8d866c78
Source dataset
uspto-grants-2013_06
Patent number
US08461170B2

Reaction notes

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