反应详情

Ethanol (15 ml) and ethyl acetate (3.00 ml) were added to a flask charged with (3R,4S)—N-benzyl-3-fluoro-1-(3-methoxy-4-nitrophenyl)piperidin-4-amine (INTERMEDIATE 47) (1.4 g, 3.90 mmol) and Pd/C (0.415 g, 0.39 mmol). The flask was degassed and filled with H2. The reaction was stirred at RT for 2 h under hydrogen balloon. The reaction mixture was filtered through a pad of Celite® and the filtrate was concentrated under reduced pressure to give the title product (0.840 g, 90%).

1. customThe flask was degassed
2. additionfilled with H2
3. filtrationThe reaction mixture was filtered through a pad of Celite®
4. concentrationthe filtrate was concentrated under reduced pressure