3-(2,5-Dichloropyrimidin-4-yl)-1H-indole → N-(4-(4-amino-3,3-dimethylpiperidin-1-yl)-2-methoxyphenyl)-5-chloro-4-(1H-indol-3-yl)pyrimidin-2-amine

HRID 1256045Notes

Reaction equation

HRID 1256045 reaction equation
Cl[C:2]1[N:7]=[C:6]([C:8]2[C:16]3[C:11](=[CH:12][CH:13]=[CH:14][CH:15]=3)[NH:10][CH:9]=2)[C:5]([Cl:17])=[CH:4][N:3]=1.[NH2:18][C:19]1[CH:24]=[CH:23][C:22]([N:25]2[CH2:30][CH2:29][CH:28]([NH2:31])[C:27]([CH3:33])([CH3:32])[CH2:26]2)=[CH:21][C:20]=1[O:34][CH3:35]>>[NH2:31][CH:28]1[CH2:29][CH2:30][N:25]([C:22]2[CH:23]=[CH:24][C:19]([NH:18][C:2]3[N:7]=[C:6]([C:8]4[C:16]5[C:11](=[CH:12][CH:13]=[CH:14][CH:15]=5)[NH:10][CH:9]=4)[C:5]([Cl:17])=[CH:4][N:3]=3)=[C:20]([O:34][CH3:35])[CH:21]=2)[CH2:26][C:27]1([CH3:33])[CH3:32]

Participants

3

Reactant 2

HCID 566553763-(2,5-Dichloropyrimidin-4-yl)-1H-indole2×HCID 58071506HCID 58071506, compound2×

Product 1

HCID 66710180N-(4-(4-amino-3,3-dimethylpiperidin-1-yl)-2-methoxyphenyl)-5-chloro-4-(1H-indol-3-yl)pyrimidin-2-amine

Procedure

Starting materials: 3-(2,5-dichloropyrimidin-4-yl)-1H-indole (Intermediate 2) and 1-(4-amino-3-methoxyphenyl)-3,3-dimethylpiperidin-4-amine (180 mg, 0.72 mmol) (Intermediate 43).

Sources & evidence

ORD record
ord-70c0a4734b724b2baa6f149b1ecca63c
Source dataset
uspto-grants-2013_06
Patent number
US08461170B2

Reaction notes

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