HuagongsheHuagongshe Chemistry Print Report · For research reference only
3-(2,5-Dichloropyrimidin-4-yl)-1H-indole → N-(4-(4-amino-3,3-dimethylpiperidin-1-yl)-2-methoxyphenyl)-5-chloro-4-(1H-indol-3-yl)pyrimidin-2-amine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 3-(2,5-Dichloropyrimidin-4-yl)-1H-indole | HCID 56655376 | — |
| Reactant | HCID 58071506 | HCID 58071506 | — |
| Product | N-(4-(4-amino-3,3-dimethylpiperidin-1-yl)-2-methoxyphenyl)-5-chloro-4-(1H-indol-3-yl)pyrimidin-2-amine | HCID 66710180 | — |
Reaction Steps
Starting materials: 3-(2,5-dichloropyrimidin-4-yl)-1H-indole (Intermediate 2) and 1-(4-amino-3-methoxyphenyl)-3,3-dimethylpiperidin-4-amine (180 mg, 0.72 mmol) (Intermediate 43).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08461170B2 |
| Source dataset | uspto-grants-2013_06 |
| ORD ID | ord-70c0a4734b724b2baa6f149b1ecca63c |
| Source note | uspto-grants-2013_06 |