3-(2,5-Dichloropyrimidin-4-yl)-1H-indole → 5-chloro-N-(4-(3,3-dimethyl-4-(methylamino)piperidin-1-yl)-2-methoxyphenyl)-4-(1H-indol-3-yl)pyrimidin-2-amine

HRID 1256046Notes

Reaction equation

HRID 1256046 reaction equation
Cl[C:2]1[N:7]=[C:6]([C:8]2[C:16]3[C:11](=[CH:12][CH:13]=[CH:14][CH:15]=3)[NH:10][CH:9]=2)[C:5]([Cl:17])=[CH:4][N:3]=1.[NH2:18][C:19]1[CH:24]=[CH:23][C:22]([N:25]2[CH2:30][CH2:29][CH:28]([NH:31][CH3:32])[C:27]([CH3:34])([CH3:33])[CH2:26]2)=[CH:21][C:20]=1[O:35][CH3:36]>>[Cl:17][C:5]1[C:6]([C:8]2[C:16]3[C:11](=[CH:12][CH:13]=[CH:14][CH:15]=3)[NH:10][CH:9]=2)=[N:7][C:2]([NH:18][C:19]2[CH:24]=[CH:23][C:22]([N:25]3[CH2:30][CH2:29][CH:28]([NH:31][CH3:32])[C:27]([CH3:33])([CH3:34])[CH2:26]3)=[CH:21][C:20]=2[O:35][CH3:36])=[N:3][CH:4]=1

Participants

3

Reactant 2

HCID 566553763-(2,5-Dichloropyrimidin-4-yl)-1H-indole2×HCID 580714481-(4-amino-3-methoxyphenyl)-N,3,3-trimethylpiperidin-4-amine2×

Product 1

HCID 580714265-chloro-N-(4-(3,3-dimethyl-4-(methylamino)piperidin-1-yl)-2-methoxyphenyl)-4-(1H-indol-3-yl)pyrimidin-2-amine

Procedure

Starting materials: 3-(2,5-dichloropyrimidm-4-yl)-1H-indole (INTERMEDIATE 2) and), 1-(4-amino-3-methoxyphenyl)-N,3,3-trimethylpiperidin-4-amine (INTERMEDIATE 44).

Sources & evidence

ORD record
ord-c428bf3cb47f4b818a4e398dc5c827b8
Source dataset
uspto-grants-2013_06
Patent number
US08461170B2

Reaction notes

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