HuagongsheHuagongshe Chemistry Print Report · For research reference only
3-(2,5-Dichloropyrimidin-4-yl)-1H-indole → 5-chloro-N-(4-(3,3-dimethyl-4-(methylamino)piperidin-1-yl)-2-methoxyphenyl)-4-(1H-indol-3-yl)pyrimidin-2-amine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 3-(2,5-Dichloropyrimidin-4-yl)-1H-indole | HCID 56655376 | — |
| Reactant | 1-(4-amino-3-methoxyphenyl)-N,3,3-trimethylpiperidin-4-amine | HCID 58071448 | — |
| Product | 5-chloro-N-(4-(3,3-dimethyl-4-(methylamino)piperidin-1-yl)-2-methoxyphenyl)-4-(1H-indol-3-yl)pyrimidin-2-amine | HCID 58071426 | — |
Reaction Steps
Starting materials: 3-(2,5-dichloropyrimidm-4-yl)-1H-indole (INTERMEDIATE 2) and), 1-(4-amino-3-methoxyphenyl)-N,3,3-trimethylpiperidin-4-amine (INTERMEDIATE 44).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08461170B2 |
| Source dataset | uspto-grants-2013_06 |
| ORD ID | ord-c428bf3cb47f4b818a4e398dc5c827b8 |
| Source note | uspto-grants-2013_06 |