2-Methoxy-4-(4-(4-methylpiperazin-1-yl)piperidin-1-yl)aniline → 5-fluoro-N-(2-methoxy-4-(4-(4-methylpiperazin-1-yl)piperidin-1-yl)phenyl)-4-(1-methyl-1H-indol-3-yl)pyrimidin-2-amine

HRID 1256050Notes

Reaction equation

HRID 1256050 reaction equation
Cl[C:2]1[N:7]=[C:6]([C:8]2[C:16]3[C:11](=[CH:12][CH:13]=[CH:14][CH:15]=3)[N:10]([CH3:17])[CH:9]=2)[C:5]([F:18])=[CH:4][N:3]=1.[CH3:19][O:20][C:21]1[CH:27]=[C:26]([N:28]2[CH2:33][CH2:32][CH:31]([N:34]3[CH2:39][CH2:38][N:37]([CH3:40])[CH2:36][CH2:35]3)[CH2:30][CH2:29]2)[CH:25]=[CH:24][C:22]=1[NH2:23]>>[F:18][C:5]1[C:6]([C:8]2[C:16]3[C:11](=[CH:12][CH:13]=[CH:14][CH:15]=3)[N:10]([CH3:17])[CH:9]=2)=[N:7][C:2]([NH:23][C:22]2[CH:24]=[CH:25][C:26]([N:28]3[CH2:33][CH2:32][CH:31]([N:34]4[CH2:35][CH2:36][N:37]([CH3:40])[CH2:38][CH2:39]4)[CH2:30][CH2:29]3)=[CH:27][C:21]=2[O:20][CH3:19])=[N:3][CH:4]=1

Participants

3

Reactant 2

HCID 457899912-Methoxy-4-(4-(4-methylpiperazin-1-yl)piperidin-1-yl)aniline2×HCID 580715123-(2-chloro-5-fluoropyrimidin-4-yl)-1-methyl-1H-indole2×

Product 1

HCID 580714345-fluoro-N-(2-methoxy-4-(4-(4-methylpiperazin-1-yl)piperidin-1-yl)phenyl)-4-(1-methyl-1H-indol-3-yl)pyrimidin-2-amine

Procedure

Starting materials: 3-(2-chloro-5-fluoropyrimidin-4-yl)-1-methyl-1H-indole (INTERMEDIATE 50) and 2-methoxy-4-(4-(4-methylpiperazin-1-yl)piperidin-1-yl)aniline (INTERMEDIATE 27).

Sources & evidence

ORD record
ord-1c41a948fc174409ae0ab526cc979979
Source dataset
uspto-grants-2013_06
Patent number
US08461170B2

Reaction notes

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