HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Methoxy-4-(4-(4-methylpiperazin-1-yl)piperidin-1-yl)aniline → 5-fluoro-N-(2-methoxy-4-(4-(4-methylpiperazin-1-yl)piperidin-1-yl)phenyl)-4-(1-methyl-1H-indol-3-yl)pyrimidin-2-amine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Methoxy-4-(4-(4-methylpiperazin-1-yl)piperidin-1-yl)aniline | HCID 45789991 | — |
| Reactant | 3-(2-chloro-5-fluoropyrimidin-4-yl)-1-methyl-1H-indole | HCID 58071512 | — |
| Product | 5-fluoro-N-(2-methoxy-4-(4-(4-methylpiperazin-1-yl)piperidin-1-yl)phenyl)-4-(1-methyl-1H-indol-3-yl)pyrimidin-2-amine | HCID 58071434 | — |
Reaction Steps
Starting materials: 3-(2-chloro-5-fluoropyrimidin-4-yl)-1-methyl-1H-indole (INTERMEDIATE 50) and 2-methoxy-4-(4-(4-methylpiperazin-1-yl)piperidin-1-yl)aniline (INTERMEDIATE 27).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08461170B2 |
| Source dataset | uspto-grants-2013_06 |
| ORD ID | ord-1c41a948fc174409ae0ab526cc979979 |
| Source note | uspto-grants-2013_06 |