HuagongsheHuagongshe Chemistry Print Report · For research reference only
Water → 3-Nitrophenylacetonitrile
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Water | HCID 962 | — |
| Reactant | Sodium Cyanide | HCID 8929 | — |
| Reactant | Benzene, 1-(bromomethyl)-3-nitro- | HCID 77568 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | 3-Nitrophenylacetonitrile | HCID 12125 | 44% |
Reaction Steps
A solution of 1-(bromomethyl)-3-nitrobenzene (30 g, 0.139 mol) and NaCN (10.21 g, 0.208 mol) in DMF (150 mL) was stirred at 50° C. for 5 hrs. The mixture was poured into water and extracted with ethyl acetate. The combined organic layer were dried, concentrated and purified by silica-gel column chromatography (PE:EA 20:1˜6:1) to give compound 2-(3-nitrophenyl)acetonitrile (9.9 g, yield 44%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08461134B2 |
| Source dataset | uspto-grants-2013_06 |
| ORD ID | ord-726313acd1234971b02d494a3ea72bf8 |
| Source note | uspto-grants-2013_06 |