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HRID1256076

反应详情

EQUATION

反应方程式

HRID 1256076 的结构方程式

REACTANTS

反应物

3
结构：O
HCID962

Water

H2O

结构：[C-]#N.[Na+]
HCID8929

Sodium cyanide (Na(CN))

CNNa

结构：O=[N+]([O-])c1cccc(CBr)c1
HCID77568

Benzene, 1-(bromomethyl)-3-nitro-

C7H6BrNO2

PRODUCTS

生成物

1
结构：N#CCc1cccc([N+](=O)[O-])c1
HCID12125

Acetonitrile, (m-nitrophenyl)-

C8H6N2O2

收率 44%

AUXILIARIES

试剂、催化剂与溶剂

1
结构：CN(C)C=O
溶剂HCID6228

N,N-Dimethylformamide

C3H7NO

PROCEDURE

实验过程

A solution of 1-(bromomethyl)-3-nitrobenzene (30 g, 0.139 mol) and NaCN (10.21 g, 0.208 mol) in DMF (150 mL) was stirred at 50° C. for 5 hrs. The mixture was poured into water and extracted with ethyl acetate. The combined organic layer were dried, concentrated and purified by silica-gel column chromatography (PE:EA 20:1˜6:1) to give compound 2-(3-nitrophenyl)acetonitrile (9.9 g, yield 44%).

WORKUP

后处理

  1. extractionextracted with ethyl acetate
  2. customThe combined organic layer were dried
  3. concentrationconcentrated
  4. custompurified by silica-gel column chromatography (PE:EA 20:1˜6:1)