反应详情

温度

60 °C

A solution of 1-(chloromethyl)-3-nitrobenzene (10.0 g, 58.1 mmol) in DMF (30 mL) was stirred at room temperature, then sodium propane-1-thiolate (5.7 g, 58.1 mmol) was added, followed by stirring at 60° C. overnight. After water was added, the aqueous layer was extracted with ethyl acetate 3 times. The combined organic phase was washed with brine, dried over sodium sulfate and concentrated to give (3-nitrobenzyl)(propyl)sulfane (11.2 g, yield 91%).

1. extractionthe aqueous layer was extracted with ethyl acetate 3 times
2. washThe combined organic phase was washed with brine
3. dry with materialdried over sodium sulfate
4. concentrationconcentrated