HuagongsheHuagongshe Chemistry Print Report · For research reference only
Pyridine → 1-[6-Phenyl-5-(4-trifluoromethyl-phenyl)-pyridin-2-yl]-ethanone O-Methyl-oxime
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Pyridine | HCID 1049 | — |
| Reactant | O-Methylhydroxylamine hydrochloride | HCID 521874 | — |
| Reactant | 1-[6-Phenyl-5-(4-trifluoromethyl-phenyl)-pyridin-2-yl]-ethanone | HCID 59338806 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | 1-[6-Phenyl-5-(4-trifluoromethyl-phenyl)-pyridin-2-yl]-ethanone O-Methyl-oxime | HCID 72258473 | — |
Reaction Steps
Following General Procedure P, 1-[6-phenyl-5-(4-trifluoromethyl-phenyl)-pyridin-2-yl]-ethanone (Compound 77, 15 mg, 0.04 mmol), NH2OMe—HCl (15 mg, 0.18 mmol) and pyridine (14 mg, 0.18 mmol) in EtOH (2 ml) were reacted to give title compound as a white solid. (12 mg, 75%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07728014B2 |
| Source dataset | uspto-grants-2010_06 |
| ORD ID | ord-abe31fa958a347139df4202b303ff838 |
| Source note | uspto-grants-2010_06 |