Pyridine → 1-[6-Phenyl-5-(4-trifluoromethyl-phenyl)-pyridin-2-yl]-ethanone O-Methyl-oxime

HRID 12562Notes

Reaction equation

HRID 12562 reaction equation
[C:1]1([C:7]2[N:12]=[C:11]([C:13](=O)[CH3:14])[CH:10]=[CH:9][C:8]=2[C:16]2[CH:21]=[CH:20][C:19]([C:22]([F:25])([F:24])[F:23])=[CH:18][CH:17]=2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[NH2:26][O:27][CH3:28].Cl.N1C=CC=CC=1>CCO>[CH3:28][O:27][N:26]=[C:13]([C:11]1[CH:10]=[CH:9][C:8]([C:16]2[CH:17]=[CH:18][C:19]([C:22]([F:24])([F:25])[F:23])=[CH:20][CH:21]=2)=[C:7]([C:1]2[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=2)[N:12]=1)[CH3:14]

Participants

5

Reactant 3

HCID 1049PyridineHCID 521874O-Methylhydroxylamine hydrochlorideHCID 593388061-[6-Phenyl-5-(4-trifluoromethyl-phenyl)-pyridin-2-yl]-ethanone2×

Product 1

HCID 722584731-[6-Phenyl-5-(4-trifluoromethyl-phenyl)-pyridin-2-yl]-ethanone O-Methyl-oxime

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

Following General Procedure P, 1-[6-phenyl-5-(4-trifluoromethyl-phenyl)-pyridin-2-yl]-ethanone (Compound 77, 15 mg, 0.04 mmol), NH2OMe—HCl (15 mg, 0.18 mmol) and pyridine (14 mg, 0.18 mmol) in EtOH (2 ml) were reacted to give title compound as a white solid. (12 mg, 75%).

Workup

  1. customwere reacted

Sources & evidence

ORD record
ord-abe31fa958a347139df4202b303ff838
Source dataset
uspto-grants-2010_06
Patent number
US07728014B2

Reaction notes

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