N-methyl-2-pyrrolidone → HCID 43089837, compound

HRID 1256615Notes

Reaction equation

HRID 1256615 reaction equation
F[C:2]1[CH:7]=[CH:6][C:5]([C:8]([F:11])([F:10])[F:9])=[CH:4][C:3]=1[N+:12]([O-:14])=[O:13].CN1CCCC1=O.[CH:22]([NH2:26])([CH2:24][CH3:25])[CH3:23]>O>[CH:22]([NH:26][C:2]1[CH:7]=[CH:6][C:5]([C:8]([F:11])([F:10])[F:9])=[CH:4][C:3]=1[N+:12]([O-:14])=[O:13])([CH2:24][CH3:25])[CH3:23]

Participants

5

Reactant 3

HCID 13387N-methyl-2-pyrrolidoneHCID 24874Sec-ButylamineHCID 677784-Fluoro-3-nitrobenzotrifluoride

Product 1

HCID 43089837HCID 43089837, compoundYield 88.1%

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

To a mixture of 1.05 g of 4-fluoro-3-nitro-benzo trifluoride and 10 ml of N-methylpyrrolidone was added 1.10 g of sec-butylamine under ice cool, and the mixture was heated up to room temperature and stirred for 1.5 hours. Into the reaction mixture was poured water, and the deposited solid was collected by filtration. This solid was washed with water, then, dried under reduced pressure to obtain 1.16 g of N-sec-butyl-2-nitro-4-trifluoromethylaniline.

Workup

  1. temperaturecool
  2. filtrationthe deposited solid was collected by filtration
  3. washThis solid was washed with water
  4. customdried under reduced pressure

Sources & evidence

ORD record
ord-323bf0eaa5d247b0b504976114e42d39
Source dataset
uspto-grants-2013_06
Patent number
US08461181B2

Reaction notes

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