反应详情

To a suspension of 5-(3,5-difluoro-benzenesulfonyl)-3-[2-(1,3-dioxo-1,3-dihydro-isoindol-2-ylmethyl)-benzoylamino]-6,6-dimethyl-5,6-dihydro-4H-pyrrolo[3,4-c]pyrazole-2-carboxylic acid ethyl ester (0.23 g, 0.34 mmol) in methanol (15 mL) and dichloromethane (1.5 mL) was added hydrazine hydrate (50 microL, 1.02 mmol). After stirring at reflux for 1 hour the volatiles were removed under reduced pressure and the residue purified by flash chromatography on silica gel eluting with dichloromethane/methanol/7N NH3 in methanol 95:4:1 affording the title compound as colorless oil (93 mg).

1. temperatureat reflux for 1 hour the volatiles
2. customwere removed under reduced pressure
3. customthe residue purified by flash chromatography on silica gel eluting with dichloromethane/methanol/7N NH3 in methanol 95:4:1 affording the title compound as colorless oil (93 mg)