Acetic Anhydride → Phenol, 3-bromo-, 1-acetate

HRID 1256694Notes

Reaction equation

HRID 1256694 reaction equation
[Br:1][C:2]1[CH:3]=[C:4]([OH:8])[CH:5]=[CH:6][CH:7]=1.C(N(CC)CC)C.[C:16](OC(=O)C)(=[O:18])[CH3:17]>ClCCl>[C:16]([O:8][C:4]1[CH:5]=[CH:6][CH:7]=[C:2]([Br:1])[CH:3]=1)(=[O:18])[CH3:17]

Participants

5

Reactant 3

HCID 7918Acetic AnhydrideHCID 8471TriethylamineHCID 115633-Bromophenol

Product 1

HCID 141946Phenol, 3-bromo-, 1-acetate

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

3-bromophenol was dissolved in dichloromethane. Triethylamine (1 eq) and acetic anhydride (2 eq) were added and the mixture was stirred at room temperature for 5 hours. The solvent was eliminated by vacuum evaporation. The evaporation residue was taken up in dichloromethane then dried on magnesium sulfate. The solvent was eliminated by vacuum evaporation.

Workup

  1. customThe solvent was eliminated by vacuum evaporation
  2. customthen dried on magnesium sulfate
  3. customThe solvent was eliminated by vacuum evaporation

Sources & evidence

ORD record
ord-178af9a794ac42caa10c0f02c5894fa2
Source dataset
uspto-grants-2013_06
Patent number
US08461212B2

Reaction notes

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