Trifluoroacetic acid → HCID 68511795, compound

HRID 1256876Notes

Reaction equation

HRID 1256876 reaction equation
C(OC([N:8]1[CH2:13][CH2:12][CH:11]([C:14]([NH:16][C:17]2[CH:47]=[CH:46][C:20]([CH2:21][CH:22]([C:30]([NH:32][S:33]([C:36]3[CH:45]=[CH:44][C:43]4[C:38](=[CH:39][CH:40]=[CH:41][CH:42]=4)[CH:37]=3)(=[O:35])=[O:34])=[O:31])[C:23]([N:25]([CH2:28][CH3:29])[CH2:26][CH3:27])=[O:24])=[CH:19][CH:18]=2)=[O:15])[CH2:10][CH2:9]1)=O)(C)(C)C.[F:48][C:49]([F:54])([F:53])[C:50]([OH:52])=[O:51]>C(Cl)Cl>[F:48][C:49]([F:54])([F:53])[C:50]([OH:52])=[O:51].[CH2:28]([N:25]([CH2:26][CH3:27])[C:23](=[O:24])[CH:22]([CH2:21][C:20]1[CH:46]=[CH:47][C:17]([NH:16][C:14]([CH:11]2[CH2:12][CH2:13][NH:8][CH2:9][CH2:10]2)=[O:15])=[CH:18][CH:19]=1)[C:30]([NH:32][S:33]([C:36]1[CH:45]=[CH:44][C:43]2[C:38](=[CH:39][CH:40]=[CH:41][CH:42]=2)[CH:37]=1)(=[O:34])=[O:35])=[O:31])[CH3:29]

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 68510389HCID 68510389, compound

Product 1

HCID 68511795HCID 68511795, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

To a solution of the compound (250 mg) obtained in Example 17 in methylene chloride (10 mL) was added trifluoroacetic acid (3 mL) at room temperature, and the mixture was stirred for 16 hr. After concentration under reduced pressure, an ether/chloroform mixture was added, and the precipitate was collected by filtration to give the title compound (247 mg) as a white solid.

Workup

  1. concentrationAfter concentration under reduced pressure
  2. additionan ether/chloroform mixture was added
  3. filtrationthe precipitate was collected by filtration

Sources & evidence

ORD record
ord-bd7447197c83403da85e5eadf5d3edf6
Source dataset
uspto-grants-2013_06
Patent number
US08461209B2

Reaction notes

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