Diethyl Malonate → HCID 14875731, compound

HRID 1256882Notes

Reaction equation

HRID 1256882 reaction equation
[C:1]([O:9][CH2:10][CH3:11])(=[O:8])[CH2:2][C:3]([O:5][CH2:6][CH3:7])=[O:4].Br.Br[CH2:14][C:15]1[CH:20]=[CH:19][N:18]=[CH:17][CH:16]=1>>[N:18]1[CH:19]=[CH:20][C:15]([CH2:14][CH:2]([C:3]([O:5][CH2:6][CH3:7])=[O:4])[C:1]([O:9][CH2:10][CH3:11])=[O:8])=[CH:16][CH:17]=1

Participants

3

Reactant 2

HCID 7761Diethyl MalonateHCID 127522194-(Bromomethyl)pyridine hbr

Product 1

HCID 14875731HCID 14875731, compoundYield 38.5%

Procedure

In the same manner as in Example 6 (1), a crude product was obtained using diethyl malonate (6.41 g) and 4-(bromomethyl)pyridine hydrobromide (10.1 g). This was purified by silica gel column chromatography to give the title compound (3.86 g) as an oil.

Workup

  1. customThis was purified by silica gel column chromatography

Sources & evidence

ORD record
ord-a3186d06b1fd492b961991bef5fa673b
Source dataset
uspto-grants-2013_06
Patent number
US08461209B2

Reaction notes

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