HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-(4-Pyridyl)piperazine → 2-(4-cyanobenzyl)-N-(2-naphthylsulfonyl)-3-oxo-3-[4-(4-pyridyl)-1-piperazinyl]propanamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-(4-Pyridyl)piperazine | HCID 70517 | — |
| Reactant | 2-(4-cyanobenzyl)-N,N-diethyl-N'-(2-naphthylsulfonyl)malonamide | HCID 86645217 | — |
| Product | 2-(4-cyanobenzyl)-N-(2-naphthylsulfonyl)-3-oxo-3-[4-(4-pyridyl)-1-piperazinyl]propanamide | HCID 68509033 | 30.4% |
Reaction Steps
In the same manner as in Example 1 (4), a crude product was obtained using the compound (300 mg) obtained in Example 111 (4) and 1-(4-pyridyl)piperazine (144 mg). This was purified by silica gel column chromatography to give the title compound (109 mg) as a white powder.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08461209B2 |
| Source dataset | uspto-grants-2013_06 |
| ORD ID | ord-d748825f60314c7c9e1de7717d993e64 |
| Source note | uspto-grants-2013_06 |