HRID1256897

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID70517

1-(4-Pyridyl)piperazine

C9H13N3

结构：CCN(CC)C(=O)C(Cc1ccc(C#N)cc1)C(=O)NS(=O)(=O)c1ccc2ccccc2c1

HCID86645217

未命名化合物

PRODUCTS

生成物

结构：N#Cc1ccc(CC(C(=O)NS(=O)(=O)c2ccc3ccccc3c2)C(=O)N2CCN(c3ccncc3)CC2)cc1

HCID68509033

未命名化合物

收率 30.4%

PROCEDURE

实验过程

In the same manner as in Example 1 (4), a crude product was obtained using the compound (300 mg) obtained in Example 111 (4) and 1-(4-pyridyl)piperazine (144 mg). This was purified by silica gel column chromatography to give the title compound (109 mg) as a white powder.

WORKUP

后处理

customThis was purified by silica gel column chromatography

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-d748825f60314c7c9e1de7717d993e64
来源数据集: uspto-grants-2013_06
DOI: 10.6084/m9.figshare.5104873.v1
专利: US08461209B2
来源说明: uspto-grants-2013_06

反应 SMILES

[C:1]([C:3]1[CH:33]=[CH:32][C:6]([CH2:7][CH:8]([C:16]([NH:18][S:19]([C:22]2[CH:31]=[CH:30][C:29]3[C:24](=[CH:25][CH:26]=[CH:27][CH:28]=3)[CH:23]=2)(=[O:21])=[O:20])=[O:17])[C:9]([N:11]([CH2:14][CH3:15])[CH2:12][CH3:13])=[O:10])=[CH:5][CH:4]=1)#[N:2].[N:34]1[CH:39]=[CH:38][C:37]([N:40]2CCNCC2)=[CH:36][CH:35]=1>>[C:1]([C:3]1[CH:33]=[CH:32][C:6]([CH2:7][CH:8]([C:9](=[O:10])[N:11]2[CH2:12][CH2:13][N:40]([C:37]3[CH:38]=[CH:39][N:34]=[CH:35][CH:36]=3)[CH2:15][CH2:14]2)[C:16]([NH:18][S:19]([C:22]2[CH:31]=[CH:30][C:29]3[C:24](=[CH:25][CH:26]=[CH:27][CH:28]=3)[CH:23]=2)(=[O:20])=[O:21])=[O:17])=[CH:5][CH:4]=1)#[N:2]