1-(4-Pyridyl)piperazine → 2-(4-cyanobenzyl)-N-(2-naphthylsulfonyl)-3-oxo-3-[4-(4-pyridyl)-1-piperazinyl]propanamide

HRID 1256897Notes

Reaction equation

HRID 1256897 reaction equation
[C:1]([C:3]1[CH:33]=[CH:32][C:6]([CH2:7][CH:8]([C:16]([NH:18][S:19]([C:22]2[CH:31]=[CH:30][C:29]3[C:24](=[CH:25][CH:26]=[CH:27][CH:28]=3)[CH:23]=2)(=[O:21])=[O:20])=[O:17])[C:9]([N:11]([CH2:14][CH3:15])[CH2:12][CH3:13])=[O:10])=[CH:5][CH:4]=1)#[N:2].[N:34]1[CH:39]=[CH:38][C:37]([N:40]2CCNCC2)=[CH:36][CH:35]=1>>[C:1]([C:3]1[CH:33]=[CH:32][C:6]([CH2:7][CH:8]([C:9](=[O:10])[N:11]2[CH2:12][CH2:13][N:40]([C:37]3[CH:38]=[CH:39][N:34]=[CH:35][CH:36]=3)[CH2:15][CH2:14]2)[C:16]([NH:18][S:19]([C:22]2[CH:31]=[CH:30][C:29]3[C:24](=[CH:25][CH:26]=[CH:27][CH:28]=3)[CH:23]=2)(=[O:20])=[O:21])=[O:17])=[CH:5][CH:4]=1)#[N:2]

Participants

3

Reactant 2

HCID 705171-(4-Pyridyl)piperazineHCID 866452172-(4-cyanobenzyl)-N,N-diethyl-N'-(2-naphthylsulfonyl)malonamide

Product 1

HCID 685090332-(4-cyanobenzyl)-N-(2-naphthylsulfonyl)-3-oxo-3-[4-(4-pyridyl)-1-piperazinyl]propanamideYield 30.4%

Procedure

In the same manner as in Example 1 (4), a crude product was obtained using the compound (300 mg) obtained in Example 111 (4) and 1-(4-pyridyl)piperazine (144 mg). This was purified by silica gel column chromatography to give the title compound (109 mg) as a white powder.

Workup

  1. customThis was purified by silica gel column chromatography

Sources & evidence

ORD record
ord-d748825f60314c7c9e1de7717d993e64
Source dataset
uspto-grants-2013_06
Patent number
US08461209B2

Reaction notes

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