N-Ethylaniline → N-ethyl-N'-(2-naphthylsulfonyl)-N-phenyl-2-(2-propynyl)malonamide

HRID 1256909Notes

Reaction equation

HRID 1256909 reaction equation
[CH2:1]([N:3]([CH2:26][CH3:27])[C:4](=[O:25])[CH:5]([CH2:22][C:23]#[CH:24])[C:6]([NH:8][S:9]([C:12]1[CH:21]=[CH:20][C:19]2[C:14](=[CH:15][CH:16]=[CH:17][CH:18]=2)[CH:13]=1)(=[O:11])=[O:10])=[O:7])[CH3:2].C(N[C:31]1[CH:36]=CC=[CH:33][CH:32]=1)C>>[CH2:26]([N:3]([C:1]1[CH:33]=[CH:32][CH:31]=[CH:36][CH:2]=1)[C:4](=[O:25])[CH:5]([CH2:22][C:23]#[CH:24])[C:6]([NH:8][S:9]([C:12]1[CH:21]=[CH:20][C:19]2[C:14](=[CH:15][CH:16]=[CH:17][CH:18]=2)[CH:13]=1)(=[O:10])=[O:11])=[O:7])[CH3:27]

Participants

3

Reactant 2

HCID 7670N-EthylanilineHCID 86645224N,N-diethyl-N'-(2-naphthylsulfonyl)-2-(2-propynyl)malonamide

Product 1

HCID 86645223N-ethyl-N'-(2-naphthylsulfonyl)-N-phenyl-2-(2-propynyl)malonamide

Procedure

In the same manner as in Example 1 (4), a crude product was obtained using the compound (4.00 g) obtained in Example 152 (4) and N-ethylaniline (1.53 mL). This was purified by silica gel column chromatography to give the title compound (98 mg) as a white powder.

Workup

  1. customThis was purified by silica gel column chromatography

Sources & evidence

ORD record
ord-9a6e884a11a444489a7b55874245379a
Source dataset
uspto-grants-2013_06
Patent number
US08461209B2

Reaction notes

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