Hydrochloric Acid → HCID 68504150, compound

HRID 1256911Notes

Reaction equation

HRID 1256911 reaction equation
[Cl:1][C:2]1[CH:36]=[CH:35][C:5]([CH2:6][CH:7]([C:19]([NH:21][S:22]([C:25]2[CH:34]=[CH:33][C:32]3[C:27](=[CH:28][CH:29]=[CH:30][CH:31]=3)[CH:26]=2)(=[O:24])=[O:23])=[O:20])[C:8]([N:10]([CH2:17][CH3:18])[C:11]2[CH:16]=CC=C[CH:12]=2)=[O:9])=[CH:4][CH:3]=1.C([NH:40][C:41]1C=NC=[CH:45][CH:46]=1)(C)C.Cl>C(O)C>[ClH:1].[Cl:1][C:2]1[CH:36]=[CH:35][C:5]([CH2:6][CH:7]([C:19]([NH:21][S:22]([C:25]2[CH:34]=[CH:33][C:32]3[C:27](=[CH:28][CH:29]=[CH:30][CH:31]=3)[CH:26]=2)(=[O:24])=[O:23])=[O:20])[C:8]([N:10]([CH:11]([CH3:12])[CH3:16])[C:17]2[CH:18]=[N:40][CH:41]=[CH:46][CH:45]=2)=[O:9])=[CH:4][CH:3]=1

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 81774732405-76-8HCID 68505209HCID 68505209, compound

Product 1

HCID 68504150HCID 68504150, compoundYield 32.2%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

In the same manner as in Example 13, the object compound was obtained using the compound (418 mg) obtained in Example 267 (1) and 3-(isopropylamino)pyridine (163 mg). This was dissolved in ethanol, 1 mol/L hydrochloric acid was added, and the mixture was concentrated under reduced pressure to give the title compound (74 mg) as a white solid.

Workup

  1. customIn the same manner as in Example 13, the object compound was obtained
  2. concentrationthe mixture was concentrated under reduced pressure

Sources & evidence

ORD record
ord-f70ef8d61ddc45b290e3a13658e6c2b8
Source dataset
uspto-grants-2013_06
Patent number
US08461209B2

Reaction notes

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