HCID 22283348, compound → HCID 86641825, compound

HRID 1256993Notes

Reaction equation

HRID 1256993 reaction equation
[F:1][C:2]([F:16])([O:6][C:7]1[CH:15]=[CH:14][C:10]([C:11](Cl)=[O:12])=[CH:9][CH:8]=1)[CH:3]([F:5])[F:4].[NH2:17][C:18]([CH3:34])([CH2:21][N:22]1[N:26]=[C:25]2[C:27]([Cl:33])=[CH:28][C:29]([Cl:32])=[C:30]([Cl:31])[C:24]2=[N:23]1)[C:19]#[N:20]>C1COCC1>[C:19]([C:18]([NH:17][C:11](=[O:12])[C:10]1[CH:14]=[CH:15][C:7]([O:6][C:2]([F:16])([F:1])[CH:3]([F:5])[F:4])=[CH:8][CH:9]=1)([CH3:34])[CH2:21][N:22]1[N:26]=[C:25]2[C:27]([Cl:33])=[CH:28][C:29]([Cl:32])=[C:30]([Cl:31])[C:24]2=[N:23]1)#[N:20]

Participants

4

Reactant 2

HCID 22283348HCID 22283348, compoundHCID 666199812-Amino-2-methyl-3-(4,5,7-trichloro-2H-benzotriazol-2-yl)-propionitrile

Product 1

HCID 86641825HCID 86641825, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent2×

Procedure

Using a procedure similar to that described in Example 169, except using a solution of 4-(1,1,2,2-tetrafluoroethoxy)benzoyl chloride (0.16 mmole) in THF and a solution of 2-amino-2-methyl-3-(4,5,7-trichloro-2H-benzotriazol-2-yl)-propionitrile (0.075 mmole, described in Example 39) in THF mixed with TEA (3% v./v.), the title compound was isolated as solid residue (4.2 mg). It was dissolved in DMSO for further biological evaluation and analyzed by LCMS. MS (ES): M/Z [M+H]=524, RT=0.72 min.

Sources & evidence

ORD record
ord-9225cd726423437497569e7e909005be
Source dataset
uspto-grants-2013_06
Patent number
US08461176B2

Reaction notes

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