HCID 22283348, compound → HCID 86641829, compound

HRID 1257032Notes

Reaction equation

HRID 1257032 reaction equation
[F:1][C:2]([F:16])([O:6][C:7]1[CH:15]=[CH:14][C:10]([C:11](Cl)=[O:12])=[CH:9][CH:8]=1)[CH:3]([F:5])[F:4].[NH2:17][C:18]([CH3:34])([CH2:21][N:22]1[CH:30]=[C:29]2[C:24]([C:25]([Cl:33])=[C:26]([Cl:32])[CH:27]=[C:28]2[Cl:31])=[N:23]1)[C:19]#[N:20]>C1COCC1>[C:19]([C:18]([NH:17][C:11](=[O:12])[C:10]1[CH:14]=[CH:15][C:7]([O:6][C:2]([F:16])([F:1])[CH:3]([F:5])[F:4])=[CH:8][CH:9]=1)([CH3:34])[CH2:21][N:22]1[CH:30]=[C:29]2[C:24]([C:25]([Cl:33])=[C:26]([Cl:32])[CH:27]=[C:28]2[Cl:31])=[N:23]1)#[N:20]

Participants

4

Reactant 2

HCID 22283348HCID 22283348, compoundHCID 666208912-Amino-2-methyl-3-(4,6,7-trichloro-2H-indazol-2-yl)propionitrile

Product 1

HCID 86641829HCID 86641829, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent2×

Procedure

Using a procedure similar to that described in Example 60, except using a solution of 4-(1,1,2,2-tetrafluoroethoxy)benzoyl chloride (0.16 mmole) in THF and a solution of 2-amino-2-methyl-3-(4,6,7-trichloro-2H-indazol-2-yl)propionitrile (0.075 mmole, described in Example 147) in THF mixed with TEA (3% v./v.), the title compound was isolated as solid residue (6 mg). It was dissolved in DMSO for further biological evaluation and analyzed by LCMS. MS (ES): M/Z [M+H]=523, RT=0.73 min.

Sources & evidence

ORD record
ord-f88eb32fdf944a109550b1362f4cee31
Source dataset
uspto-grants-2013_06
Patent number
US08461176B2

Reaction notes

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