4-Phenoxybenzoyl chloride → HCID 68708854, compound

HRID 1257033Notes

Reaction equation

HRID 1257033 reaction equation
[O:1]([C:8]1[CH:16]=[CH:15][C:11]([C:12](Cl)=[O:13])=[CH:10][CH:9]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[NH2:17][C:18]([CH3:34])([CH2:21][N:22]1[CH:30]=[C:29]2[C:24]([C:25]([Cl:33])=[C:26]([Cl:32])[CH:27]=[C:28]2[Cl:31])=[N:23]1)[C:19]#[N:20]>C1COCC1>[C:19]([C:18]([NH:17][C:12](=[O:13])[C:11]1[CH:15]=[CH:16][C:8]([O:1][C:2]2[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=2)=[CH:9][CH:10]=1)([CH3:34])[CH2:21][N:22]1[CH:30]=[C:29]2[C:24]([C:25]([Cl:33])=[C:26]([Cl:32])[CH:27]=[C:28]2[Cl:31])=[N:23]1)#[N:20]

Participants

4

Reactant 2

HCID 741934-Phenoxybenzoyl chlorideHCID 666208912-Amino-2-methyl-3-(4,6,7-trichloro-2H-indazol-2-yl)propionitrile

Product 1

HCID 68708854HCID 68708854, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent2×

Procedure

Using a procedure similar to that described in Example 60, except using a solution of 4-phenoxybenzoyl chloride (0.16 mmole) in THF and a solution of 2-amino-2-methyl-3-(4,6,7-trichloro-2H-indazol-2-yl)propionitrile (0.075 mmole, described in Example 147) in THF mixed with TEA (3% v./v.), the title compound was isolated as solid residue (13 mg). It was dissolved in DMSO for further biological evaluation and analyzed by LCMS. MS (ES): M/Z [M+H]=499, RT=0.79 min.

Sources & evidence

ORD record
ord-13693cacb28e44448bbccee152c5251e
Source dataset
uspto-grants-2013_06
Patent number
US08461176B2

Reaction notes

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