Hydrogen chloride-ethyl acetate → 1-Acetylpiperazine

HRID 1257109Notes

Reaction equation

HRID 1257109 reaction equation
[C:1]([N:4]1[CH2:9][CH2:8][N:7](C(OC(C)(C)C)=O)[CH2:6][CH2:5]1)(=[O:3])[CH3:2].Cl.CCOC(C)=O>>[C:1]([N:4]1[CH2:9][CH2:8][NH:7][CH2:6][CH2:5]1)(=[O:3])[CH3:2]

Participants

3

Reactant 2

HCID 21866389Hydrogen chloride-ethyl acetateHCID 22707023Tert-butyl 4-acetylpiperazine-1-carboxylate

Product 1

HCID 837951-Acetylpiperazine

Procedure

1-Acetyl-4-tert-butoxycarbonylpiperazine was treated with 8 M HCl/EtOAc to afford the title compound in near quantitative yield.

Sources & evidence

ORD record
ord-80a0c39d1bdc4a9bb464285d1342e700
Source dataset
uspto-grants-2013_06
Patent number
US08461339B2

Reaction notes

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