Back
HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1257109Generated: November 4, 2026

Hydrogen chloride-ethyl acetate → 1-Acetylpiperazine

https://huagongshe.com/reaction/1257109

Reaction equation

Participants

RoleNameHCIDCharge
ReactantHydrogen chloride-ethyl acetateHCID 21866389—
ReactantTert-butyl 4-acetylpiperazine-1-carboxylateHCID 22707023—
Product1-AcetylpiperazineHCID 83795—

Reaction Steps

1-Acetyl-4-tert-butoxycarbonylpiperazine was treated with 8 M HCl/EtOAc to afford the title compound in near quantitative yield.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08461339B2
Source datasetuspto-grants-2013_06
ORD IDord-80a0c39d1bdc4a9bb464285d1342e700
Source noteuspto-grants-2013_06