HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
Hydrogen chloride-ethyl acetate → Isoquinolin-3-yl-(4-piperazin-1-ylmethyl-pyridin-2-yl)-amine
Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
|---|---|---|---|
| Edukt | Hydrogen chloride-ethyl acetate | HCID 21866389 | — |
| Edukt | 2-(Isoquinolin-3-ylamino)-4-(4-tert-butoxycarbonylpiperazin-1-ylmethyl)-pyridine | HCID 67175602 | — |
| Produkt | Isoquinolin-3-yl-(4-piperazin-1-ylmethyl-pyridin-2-yl)-amine | HCID 44612469 | — |
Reaktionsschritte
2-(Isoquinolin-3-ylamino)-4-(4-tert-butoxycarbonylpiperazin-1-ylmethyl)-pyridine was treated with 8 M HCl/EtOAc to afford the title compound as a salt in near quantitative yield (50 mg). 1H NMR (CDCl3, 300 MHz) δ: 3.44 (s, 4H, PyridylCH2NCH2CH2), 3.45 (s, 4H, NHCH2), 4.25 (s, 2H, pyridylCH2), 7.01-8.87 (m, 9H, isoquinolyl+pyridyl).
Herkunft & Nachweise
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patentnummer | US08461339B2 |
| Quelldatensatz | uspto-grants-2013_06 |
| ORD ID | ord-6e1513559b534a36b9eed6453a776314 |
| Quellennotiz | uspto-grants-2013_06 |