2-Bromo-1-(3,4-dichlorophenyl)ethanone → ethyl 1-{[4-(3,4-dichlorophenyl)-1,3-thiazol-2-yl]methyl}-1H-pyrazole-4-carboxylate

HRID 1257309Notes

Reaction equation

HRID 1257309 reaction equation
[NH2:1][C:2](=[S:14])[CH2:3][N:4]1[CH:8]=[C:7]([C:9]([O:11][CH2:12][CH3:13])=[O:10])[CH:6]=[N:5]1.Br[CH2:16][C:17]([C:19]1[CH:24]=[CH:23][C:22]([Cl:25])=[C:21]([Cl:26])[CH:20]=1)=O>>[Cl:26][C:21]1[CH:20]=[C:19]([C:17]2[N:1]=[C:2]([CH2:3][N:4]3[CH:8]=[C:7]([C:9]([O:11][CH2:12][CH3:13])=[O:10])[CH:6]=[N:5]3)[S:14][CH:16]=2)[CH:24]=[CH:23][C:22]=1[Cl:25]

Participants

3

Reactant 2

HCID 2447512-Bromo-1-(3,4-dichlorophenyl)ethanoneHCID 58127901Ethyl 1-(carbamothioylmethyl)-1H-pyrazole-4-carboxylate

Product 1

HCID 58127686ethyl 1-{[4-(3,4-dichlorophenyl)-1,3-thiazol-2-yl]methyl}-1H-pyrazole-4-carboxylateYield 76%

Procedure

By a reaction in the same manner as in Example 1c and using the compound (213 mg, 1.00 mmol) obtained in Example 1b and 2-bromo-1-(3,4-dichlorophenyl)ethanone (268 mg, 1.00 mmol) to give the title compound (290 mg, 76%) as colorless crystals.

Workup

  1. customBy a reaction in the same manner as in Example 1c

Sources & evidence

ORD record
ord-d56655945ce74b019f2d8bab6a5b775b
Source dataset
uspto-grants-2013_06
Patent number
US08461348B2

Reaction notes

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