Bromopyruvic Acid → 2-{[4-(ethoxycarbonyl)-1H-pyrazol-1-yl]methyl}-1,3-thiazole-4-carboxylic acid

HRID 1257311Notes

Reaction equation

HRID 1257311 reaction equation
[NH2:1][C:2](=[S:14])[CH2:3][N:4]1[CH:8]=[C:7]([C:9]([O:11][CH2:12][CH3:13])=[O:10])[CH:6]=[N:5]1.Br[CH2:16][C:17](=O)[C:18]([OH:20])=[O:19]>>[CH2:12]([O:11][C:9]([C:7]1[CH:6]=[N:5][N:4]([CH2:3][C:2]2[S:14][CH:16]=[C:17]([C:18]([OH:20])=[O:19])[N:1]=2)[CH:8]=1)=[O:10])[CH3:13]

Participants

3

Reactant 2

HCID 70684Bromopyruvic AcidHCID 58127901Ethyl 1-(carbamothioylmethyl)-1H-pyrazole-4-carboxylate

Product 1

HCID 669392482-{[4-(ethoxycarbonyl)-1H-pyrazol-1-yl]methyl}-1,3-thiazole-4-carboxylic acidYield 57.9%

Procedure

By a reaction in the same manner as in Example 1c and using the compound (1.07 g, 5.0 mmol) obtained in Example 1b and bromopyruvic acid (920 mg, 5.5 mmol), the title compound (814 mg, 57%) was obtained as bister crystals.

Workup

  1. customBy a reaction in the same manner as in Example 1c

Sources & evidence

ORD record
ord-60ac4ffba9714b88bada35d57757eaab
Source dataset
uspto-grants-2013_06
Patent number
US08461348B2

Reaction notes

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