1,3-Dichloroacetone → HCID 66939077, compound

HRID 1257411Notes

Reaction equation

HRID 1257411 reaction equation
[F:1][C:2]1[C:10]([C:11]([F:14])([F:13])[F:12])=[CH:9][CH:8]=[CH:7][C:3]=1[C:4]([NH2:6])=[O:5].[Cl:15][CH2:16][C:17](=O)[CH2:18]Cl>C1(C)C=CC=CC=1>[Cl:15][CH2:16][C:17]1[N:6]=[C:4]([C:3]2[CH:7]=[CH:8][CH:9]=[C:10]([C:11]([F:12])([F:13])[F:14])[C:2]=2[F:1])[O:5][CH:18]=1

Participants

4

Reactant 2

HCID 107931,3-DichloroacetoneHCID 6056882-Fluoro-3-(trifluoromethyl)benzamide

Product 1

HCID 66939077HCID 66939077, compoundYield 58.8%

Reagents, catalysts & solvents 1

HCID 1140TolueneSolvent

Conditions

Temperature
130 °C

Procedure

A mixture of 2-fluoro-3-(trifluoromethyl)benzamide (1.02 g), 1,3-dichloropropanone (1.27 g) and toluene (4 mL) was heated at 130° C. for 40 hr. The reaction mixture was purified by column chromatography (carrier: silica gel, eluent: hexane-ethyl acetate) to give the title compound (0.81 g) as colorless crystals.

Workup

  1. customThe reaction mixture was purified by column chromatography (carrier: silica gel, eluent: hexane-ethyl acetate)

Sources & evidence

ORD record
ord-48248b07f1f3491eb20ffc22b840e011
Source dataset
uspto-grants-2013_06
Patent number
US08461348B2

Reaction notes

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