反应详情

To methyl 4-(cyanomethyl)benzoate (5.0 g, 28.5 mmol) were added 4M hydrogen chloride-ethyl acetate solution (50 mL) and O,O-diethyl dithiophosphate (6.70 mL, 40.0 mmol), and the mixture was stirred overnight. The reaction mixture was alkalified with saturated aqueous sodium hydrogen carbonate solution and 8N aqueous sodium hydroxide solution, and extracted with ethyl acetate. The extract was washed successively with water and saturated brine, dried over sodium sulfate, and filtered by basic silica gel. The filtrate was concentrated under reduced pressure and recrystallized from ethyl acetate-tetrahydrofuran-hexane to give the title compound (4.46 g, 75%) as a colorless solid.

1. extractionextracted with ethyl acetate
2. washThe extract was washed successively with water and saturated brine
3. dry with materialdried over sodium sulfate
4. filtrationfiltered by basic silica gel
5. concentrationThe filtrate was concentrated under reduced pressure
6. customrecrystallized from ethyl acetate-tetrahydrofuran-hexane