反应详情

温度

70 °C

A solution of N-(3-fluoro-pyridin-4-yl)-benzamide (1.95 kg, 9.0 mol) in anhydrous dimethylformamide (10 L) was placed under nitrogen atmosphere and heated at 70° C. The heated solution was charged with iodoethane via dropwise addition (1.55 kg/0.795 L, 9.9 mol) with temperature monitoring. The addition caused an exoterm that raised the internal reactor temperature to 110° C. for the duration of the addition. A temperature of 100° C. was maintained for a further two hours before the reaction was cooled to room temperature. The reaction mixture was poured into ethyl acetate (50 L, pre-cooled to 5° C.) and stirred for one hour. The precipitated solid was collected by filtration and washed with ethyl acetate (3×10 L). The yellowish solid 4-benzamido-1-ethyl-3-fluoro-pyridinium iodide was dried in a tray vacuum oven at 50° C., yielding 3.25 kg. (97%). 1H NMR (400 MHz, DMSO): δ 11.37 (1H, s), 9.41 (1H, dd, J=5.86, 1.56 Hz), 8.88 (1H, dd, J=7.03, 1.56 Hz), 8.73 (1H, t, J=7.42 Hz), 7.99 (2H, d, J=8.20 Hz), 7.72 (1H, t, J=7.42 Hz), 7.61 (2H, t, J=8.20 Hz), 4.52 (2H, q, J=7.42 Hz), 1.54 (3H, t, J=7.42 Hz).

1. additionThe addition
2. temperatureraised the internal reactor temperature to 110° C.
3. additionfor the duration of the addition
4. temperatureA temperature of 100° C. was maintained for a further two hours before the reaction
5. temperaturewas cooled to room temperature
6. filtrationThe precipitated solid was collected by filtration
7. washwashed with ethyl acetate (3×10 L)
8. dry with materialThe yellowish solid 4-benzamido-1-ethyl-3-fluoro-pyridinium iodide was dried in a tray vacuum oven at 50° C.
9. customyielding 3.25 kg